A Study Of Behavior Pattern And Plasma Catecholamine In Patients With Ventricular Premature Beats

AIM: To investigate the correlation and clinical significance between plasma noradrenaline, adrenaline, behavior pattern and ventricular premature beats. Methods: A study was conducted on 80 patients with sympotomic ventricular premature beats and without clinical organic heart disease as experimented group, 160 normals volunteered as the control group, they were surveyed by Type A Behavior Pattern (TABP) Questionnaire. Plasma noradrenaline, adrenaline of 60 patients and 30 normals were measured by an enzyme-linked immunosorbent assay (ELISA). The ventricular premature beats in patients were recorded by Holter.Results: The logarithm of the concentrations of plasma noradrensline, adrenaline in patients and controls were 3.10±0.32, 2.33±0.18; 2.90 ±0.30, 2.21±0.16 respectively, the total scores of TABP in both groups were 32.27±7.63 , 25.20±6.07 respectively. There were statistically significant differents between two groups (p<0.01). The scores of TABP were strongly related to the concentrations of plasma noradrenaline, adrenaline, the degree of the VPB (r=0.321,0.482;0.385,0.431; 0.272,0.393 respectively, p <0.01).Conclusions: People with TABP tend to be nervous and lead to excitement of sympathetic nerves, then they have greater catecholamine responses to psychological stressors. With the secretion of noradrenaline, adrenaline increasing, the stablility of the heart electric activity decreases, this can contributed to the trigger of VPBs.