The Detection And Clinical Significance Of GSH In Patients With Nasopharyngeal Carcinoma

Object: To establish a test method about Glutathione(GSH) content peripheralblood monocytes in healthy people and its reference date. To investigate theclinical significance of GSH content of peripheral blood monocytes in patientswith nasopharyngeal carcinoma.Methods: The GSH contents of periphetsl blood monocytes in 126 cases ofnasopharyngeal patients and 102 cases of healthy persons were determined by ,Tietze methods. And test the GSH content in healthy people s blood in differentsexes and different ages .The difference in contents between nasopharyngealpatients and healthy persons was observed and the recent regression ofnasopharyngeal tumor in nasopharyngeal carcinoma patients whose GSH contentwas higher or lower than the average GSH contents of healthy persons wasanalysed.Results: The GSH contents of peripheral blood monocytes in men and womenwere (133.88±72.32) ×10-9mmol/L and (141.51±58.98)×10-9mmol/L, respectively(P>0.05); the GSH contents in younger than 30 years, 30~39 years, 40~49 years, 50~59years and above 60 years were (132.99±49.16)×10-9mmol/L, (129.00±68.41)×10-9mmol/L,(132.67±47.25)×10-9mmol/L,(152.17±73.72)×10-9mmol/L, (150.84±104.27)×10-9mmol/L respectively (P>0.05). The GSH contents of peripheral 4blood monocytes in nasopharyngeal carcinoma patients and healthy personswere(140.03±53.87)×10-9mmol/L and(138.08±64.92)×10-9mmol/L, respectively.There was no significant difference(P>0.05). The GSH contents in state Ⅰ, Ⅱ, ,Ⅲ, and Ⅳ nasopharyngeal carcinoma patients blood were (135.66±50.74)×10-9mmol/L,(141.35±69.57)×10-9mmol/L,(149.55±79.40)×10-9mmol/L,(136.29±69.31)×10-9mmol/L, respectively. There was no significant difference(P>0.05). The two groups accepted the same radiotherapy. After finishedradiotherapy, the complete regression rate and partial regression rate ofnasopharyngeal tumor of the two groups were 47.7％, 52.3％ and 70.5％,29.5％, respectively(P<0.05).Conclusion: This method is simple and results are reliable. GSH cannot affect theoccurrence and development of Nasopharyngeal carcinoma. The recent regressionrate of nasopharyngeal tumor in the lower GSH content group is higher than thehigher GSH content group. The GSH content of peripheral blood monocytes can beused as an index to forecast radiosensitivity of Nasopharyngeal carcinoma and useGSH synthesis depressant to enhance the radiosensitivity.