Study On The Levels Of Plasma CGRP, PGI₂, At Ⅰ And At Ⅱ In Normal Young Descendents With Fammily History Of Essential Hypertension

Objective To study the implications of CGRP, PGI2, ATI and ATII in normal young descendents from different essential hypertension family background, plasma CGRP, PGI2, ATI and ATII levels were determined by radioimmunoassay. Methods 80 normal young descendents with or without family history of essential hypertension were randomly recruited and divided into 3 groups: 30 descendents from either father or mother with essential hypertension as study group 1; 30 descendents from both father and mother with essential hypertension as study group 2; 20 subjects from parents without essential hypertension as control group. The fasting blood samples were phlebotomized from all the subjects in the early morning. The levels of plasma CGRP, PGI2, ATI and ATII were determined by radioimmunoassay.Results 1. The plasma levels of CGRP, PGI2, ATI and ATII increased significantly in group 1 and group 2 compared with those in control group (t=2. 235-4. 376, P< 0. 01, 0. 05, 0. 05, 0. 05 respectively). Between groupl and group2, the plasma levels of CGRP, PGI2, ATI and ATII increased significantly (t=2.231-4.056,P<0. 05) 2.There were positive correlations between the levels of plasma CGRP and ATI or ATII (r=0.665,0.757 P<0.05 ,0.05 respectively); There were positive correlations among the levels of plasma PGI2 and ATI, ATII (r=0. 607, 0. 675 P<0. 05, 0. 05 respectively); There were positive correlations between the levels of plasma CGRP and PGI2 (r=0. 601 P<0.05).Conclusions 1. There are increased plasma levels of CGRP, PGI2, ATI and ATII in normal young descendents with family histories of essential hypertension. 2. It is probably because CGRP, PGI2, ATI and ATII reach a new balance at a higher level that blood pressure can be maintained at a normal level. 3. The change of vasoactive substances such as CGRP, PGI2, ATI and ATIIis hereditarily related and likely to be the pathogenesis of hypertension.4. The levels of plasma CGRP, PGI2, ATI and ATII might be some very important predictors for the possibility of developing essential hypertension in the descendents with hypertension family history in the future.