| Objective: Cytokines play an important role in modulating inflammatory and proliferative of respones, including atherosclerosis. We designed the present study to investigate the clinical significance of the alterations of the circulating levels of transforming growth factor-β1 (TGF-β1) and insulin-like growth factor-1 (IGF-1) in patients with coronary heart disease(CHD).Methods: The study group comprised 60 patients with coronary heart disease(CHD) and 28 control subjects. The CHD patients were subdivided into 2 groups: 30 with acute myocardial infarction(AMI) and 30 patients with angina pectoris(AP). 71 patients undergone semiquantitative coronary angiography, and all patients undergone echocardiography. Serum TGF-β1 and IGF-1 were detected using ELISA method in all subjects. Blood sugar and lipids were also measured simultaneously.Results: Serum TGF-β1 level significantly reduced in 60 patients with CHD compared with the controls (12.36+ 6.21ng/ml vs 32.65+ 22.71ng/ml, P<0.01).Serum IGF-1 showen the same case (51.03+26.50ng/ml vs 141.00+51.06ng/ml ,P<0.01). 30 patients with AMI showed a lower serum level of IGF-1 than 30 patients with AP(29.15 + 10.02 ng/ml vs 72.90+ 18.40ng/mh P<0.01). A weak positive correlation emerged between TGF-β1 and IGF-1 (rs=0.291, P<0.05) and these two cytokines showed no correlation with blood sugar and lipids. IGF-1 showed an inverse correlation with scores of coronary artery lesion(rs=-0.435, P<0.01) in 41 patients undergone semiquantitativecoronary angiogrophy and a positive correlation with EF (rs=0.533, P<0.01) in 60 patients with CHD.Conclusion: The findings suggested that serum levels of TGF-β1 and IGF-1 reduced in patients with CHD, especially in patients with AMI. IGF-1 showed some extent protective effect to coronary artery. Increased serum levels of IGF-1 showed some extent protective effect to cardiac function in patients with CHD.
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