The Relationship Between Insulin Resistance And Hypertensive Target Organ Damage Of Heart

Objective To investigate the relationship between insulin resistance and hypertensive target organ damage, if insulin resistance is a risk factor in hypertensive developing . Methods A total of 150 persons were included. All subjects were classified as normal group and hypertensive group. According UCG to measure left ventricular mass index(LVMI) and ejection fraction(EF), the hypertensive group was further divided into three group as follows: (1) without target organ damage, (2) with left ventricular hypertrophy, (3) with heart failure . Total triglycerides, cholesterol, high density lipoprotein-cholesterol(HDL-C), low density lipoprotein- cholesterol, fasting plasma glucose, fasting insulin(FINS) and uric acid were measured . body mass index(BMI) was measured also. Homeostasis model assessment insulin resistance index (HOMA-ER) was applied to estimate insulin resistance. Results According to analysis of variance ,we found a significant step-by-step increase in FINS, HOMA-IR among subgroups, there were statistically difference among each groups (p<0.05), HDL-C was lower in heart failure group (p<0.05); Logistic regression analysis showed HOMA-IR were risk factors in left ventricular hypertrophy, HOMA-IR was a risk factor in hypertensive heart failure also. Linear correlative analysis on insulin resistance parameter showed FINS and ISI were significant correlative with HOMA-IR. Conclusion The degree of Insulin resistance was aggravating with hypertensive target organ damage.