The Clinical Significance Of Serum Interleukin-6, Interleukin-8 And Interleukin-10 Levels In Patients With Lung Cancer

Objective To study clinical significance and the relationship between the serum levels of interleukin-6(IL-6), interleukin-8(IL-8) and interleukin-10(IL-10) and disease progression, prognosis in the patients with lung cancer. Method The serum levels of IL-6, IL-8 and IL-10 were measured in 47 patients with TNM stage II, III and IV lung cancer and healthy control by using an enzyme-linked immunosorbent assay(ELISA). Resnlt The serum IL-6, IL-8 and IL-10 levels of the patients with lung cancer were significantly higher than those of the healthy control(P<0.0001). Serum levels of IL-6, IL-8 and IL-10 were correlated significantly with tumor's TNM stages(P<0.05). And those were not assorciated with tumor's pathologic classification(P>0.05). After the chemotherapy, the serum levels of IL-6, IL-8 and IL-10 were decreased significantly in patients with stable stage and partial remission but increased in IL-6 serum level in patients with progression. Conclusion Themeasurement of 11-6, IL-8 and IL-10 serum levels in the patients with lung cancer is a reliable, sensitive and easy method. An elevation of IL-6, IL-8 and IL-10 serum level in the patients with lung cancer may serve as an indication of disease progression and an unfavourable prognosis.