| Objective: To investigate the relationship between coronaryartery status and fasting glucose , postload glucose and HbA1cconcentrations in patients with coronary artery disease .Our aimis to find which of them was of more importance forpredicting coronary heart disease.The risk factors in coronaryartery disease were analysised by Spearman's rank correlationand Logistic regression analysis. Method: A total of 119 patients(mean age 57.02±10.52years ,men 89, women 30) were selected consecutivly fromJanuary 2003 to January 2004. All subjects had previouslyknown clinical evidence of CHD confirmed by typicalhistory ,positive results of ECG or exercise testing,orhistory of myocardial infraction. The reason for exclusion werepreviously diagnosed as diabetes or using of hyperglycemicdrugs, valvular disease ,and acute coronarial events .Coroary angiography was performed in all patients .The coronaryangiograms were evaluated by experenced cardiologists whowere unware of the glucose toleranced status of the patients . Thedegree of luminal narrowing was recorded in percentage ofprestenotic diameter .Internal luminal narrowing of >50% was 5considered as significiant . In all patients ,an oral glucosetoleranced test(OGTT, 75g glucose load) was performed between8A.M—10A.M. after over 12 hours fast, with the patients insitting position and not allowed smoking , drinkingalcohol ,coffee, or performing drastic physical exercise for 10hours before the test. The blood samples for glucose were takenat 0, 120 minete .Before the test ,blood samples were collectedfor determination of HbA1c .Total cholesterol(TC),triglyceride(TG), HDL cholesterol(HDL-C), LDL cholesterol(LDL-C) concentrations. BMI, blood pressure were alsomeasured. Glucose concentrations were estimated immediatelyusing oxidase method. World Health Organization criteria(1999)was used for classifying the OGTT results. Statistical analysiswas performed using ANOVA test. The comparision ofprevalence data among groups was performed by X2 test.Spearman's rank correlation analysis and Logistic regressionwere performed to establish metabolic factors independentlyrelated to the number of involved vessels . Data wereexpressed as means+s . P<0.05 was considered statisticallysignificant . Results : According to the results of coronary angiogrphy,patients were divided into four groups : no significiant stenosis inthe coronary arteries (group 0,n=8), one-vessel disease (group1 ,n=30), two-vissel disease(group 2,n=30),three-visseldisease(group 3,n=51).The results of age , BMI, SBP, DBP, andTC , TG, LDL-C, postload glucose ( 5.96+1.05 mmol/l, 67.37+1.43 mmol/l, 8.93+1.42 mmol/l, 9.67+2.23 mmol/l,respectively), HbA1c(4.46+0.53%, 5.54+0.52%, 6.37+0.64%,6.57+1.05%,,respectively) concentrations were statisticallydifferent between the groups(p<0.05) .Higher age, BMI and TC,TG, LDL-C, postload glucose, HbA1c concentrations wereobserved in groups with more serious changes. There were nosignificant differences in fasting glucose concentrations( 5.10+0.63 mmol/l, 5.23+1.60 mmol/l, 5.52+1.49 mmol/l,5.56+1.19 mmol/l, respectively)between four groups (p>0.05).HDL-C was also statistically different in the four groups .LowerHDL-C could be seen in patients with more serious changes.43.2% patients with coronary heart disease conformed by cornaryangiography demostrated disturbances of glucosemetablism( IGT and DM). Generally disturbed glucose tolerancewas presently more ofen in patients with two- and three-vesseldesease comparied with those of one-vessel disease and nosignificiant stenosis in the coronary arteries (55 % vs 50 % vs23%vs12.5%, respectly). Diffusing changes were more frequentin DM and IGT groups than NGT gr...
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