| Objective In vitro and in vivo animal experiments and in a clinical study, percutaneous microwave coagulation therapy(PMCT) was administered to evaluate this method as a therapy option for liver cancer. Methods HSE-8M PMCT equipment was utilized at 2450 MHz in frequency. As an in vitro study, a microwave electrode was inserted into pig liver with different power outputs. After PMCT on fresh pig livers with Model HSE-8M system, we assessed the 3-D images of coagulation areas with TOMTEC ECHO SCAN 3-D system. In the animal experiment, PMCT was performed on 4 rabbit livers for 4 times (30W60s) and at laparotomy on one rabbit liver for 6 times (30W60s 3 times and 60W60s 3 times) . Clinically, 32 cases of 51 cancerous nodules were treated, then the results were evaluated using LEVOVIST, 3-D ultrasound, and Lab findings. Results As an in vitro study, the results showed that the coagulation areas in 3-D were drip-like in shape under the condition of 180s40W, 120s and 180s (45W, SOW, 55W, 60W and 65W) with the volume range of 3.41-5.54cm3. Contrary to 2-D, coagulation volumes estimated by 3-D were accorded with the actual volumes (p>0.05). In the animal experiments, cellular degeneration and incomplete necrosis were noted microscopically immediately after MCT; at day 3, complete necrosis occurred in most cells; at day 5, complete irreversible necrosis occurred in all the lesions; and at day 7-10, necrotic lesions were surrounded by fibrosis. Clinically, after PMCT, all of 51 nodules had smaller size and disappearance or reduction of blood flow. AFP dropped in 16/20 patients with Hepatocellular carcinoma (HCC) , among them, one patient's AFP had a decrease of nearly 30 thousand units from 32626.24 to 2627.57. The efficacy of PMCT is apparent without severe complications. Conclusion Ultrasound-guided PMCT is one of effective treatments for liver cancer.
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