Clinical Observation And Its Mechanism On Treating Unstable Angina By Luomaishutong Granule

Objective: To observe the clinical effect of Luomaishutong Granule on unstable angina and explore its mechanism of effect. Methods: 82 patients of coronary heart disease with unstable angina pectoris(UAP)were divided randomly into treatment group(40cases) and control group (42 cases) .Conventional western medical therapy was given to both groups .At the same time ,the treatment group were dosed Luomaishutong Granule .The changes of clinical symptom and laboratory indexes were observed before and after treatment in both groups. Result: In the treatment group , the total effective rate of meliorating symptoms and the remarkable rate were respectively 97.50% and 77.50% , which were significantly better than those of the control group, P<0.05 or P<0.01.Meanwhile,the level of the TXB2, ET-1 ,APTT, TT, P-selectin, WBC, ESR, CRP, Fg were decreased and the level of NO were increased remarkably after treatment ,which were statically different compared with those of the control group ,P<0.05 or P< 0.01.Among of whom received coronary Angiography the fatal arrhythmia occurs rate were decreased , which were statically different compared with those of the control group ,P<0.05.Conclusion : Luomaishutong Granule is likely to obtain effect through improving endothelium function, inhibiting platelet activation, relieving spasm of coronary artery.