Expressions Of COX-2,bcl-2 And PCNA In Prostatic Carcinoma And Their Significance

Objective: To investigate the relationship between expressions of COX-2 , bcl-2 and PCNA and clinicopathological behavior in prostatic carcinoma.Methods: Immunohistochemical SP method was used to evaluate the positivities of COX-2 , bcl-2 and PCNA in 12 cases of benign prostatic hyperplasia and 70 cases of prostate carcinoma.Results: The percentage of COX-2 protein positive expression was 8.33% in benign prostatic hyperplasia, while 61.43% in prostate carcinoma. The positive stains of COX-2 , bcl-2 and PCNA protein in prostate carcinoma were significantly higher than that in benign prostatic hyperplasia (P<0.05). Positive rates for COX-2 , bcl-2 and PCNA significantly up-regulated with the decrease of the tumor cell nuclear grade and the increase of the clinical stage (P<0.05). The positive expressions of COX-2 , bcl-2 and PCNA in the group of infiltration and metastasis increased significantly (P<0.05). The expressions of bcl-2, PCNA in prostate carcinoma were correlated with that of COX-2 (P<0.05), while the expression of bcl-2 in prostate carcinoma wasn't correlated with that of PCNA (P>0.05).Conclusion: The over expression of COX-2 might be related closelyto the biological behavior of human prostate cancer, and might play an important role in the carcinogenesis and progression of prostate carcinoma by inducing high proliferation and low apoptosis.