The Expression And Significance Of Gene P53, CCK-B And SSTR-2 Receptor In Pancreatic Carcinomas

Purpose: The expressions of anti-oncogene p53 and CCK-B receptor are lower in normal pancreatid issues and higher in pancreatic carcinomas. On the contrary, expression of SSTR-2 receptor is higher in normal pancreatic issues and lower in pancreatic carcinomas.The purpose of the research is to explore the expression and the relationship among p53, CCK-B and SSTR-2 receptor in pancreatic adenocarcinomas and normal pancreatic issues. Methods: We used immunohistochemical method to examine formalin-fixed paraffin embedded samples of 30 pancreatic adenocarcinomas and 10 normal pancreatic issues for expression of the p53, CCK-B and SSTR-2. The retation between the results and the sorts of clinical characters, for example, ages, sex, diameter of the tumor, TNM staging and pathological staging, etc. Result:The positive rate of p53, CCKB and SSTR-2 were 13/30(43.33%), 18/30(60.00%) and 14/30(46.67%) respectively in pancreatic adenocarcinomas and were 0 (0/10), 0% (0/10) and 100 % (10/10) respectively in normal pancreatic issues. Significant difference was found between the two groups(p<0. 05). The expression in pancreatic adenocarcinomas are synchronously 9 positive and 8 negative between p53 and CCK-B, 9 postive and 12 negative between p53 and SSTR-2, and 12 positive and 10 netative between CCK-B and SSTR-2. There are respectively correlation in both of the last two groups. The expression of CCK-B and SSTR2 of age, sex and the tumor size was no significant difference (p>(). 05) but was of the tumor differentiatial degree (p<0. 05) .The expression of p53 was no significant difference of all above clinical marker. Conclusion: The high expression of p53 and CCKB and the low expression of SSTR2 in pancreatic adenocarcinomas means that there are multiple factors in pancreatic cancer. The corretation between them suggest that the factors are interaction and co-operation each other in the development of pancreatic carcinomas.