| Objective and BackgroundDiabetic nephropathy(DN) is the leading cause of end-stage renal dysfunction(ESRD) in many countries and it is a major cause of mortality in diabetes mellitus. Therefore, it is great significance to identify the specific pathway through which the diabetic state leads to renal dysfunction. However, the pathogenesis of microvascular complications in diabetes may be complicated, and both direct and indirect mechanism may be implicated. Since Ross postulated the view: "Atherosclerosis—an inflammatory disease" , many studies have explored that the atherosclerosis represent a series of specific cellar and molecular responses that can be described, in aggregate, as an inflammatory disease.Recently studies have postulated that CDllb/CD18 overexpression in peripheral blood Polymonphonuclear (PMN) leukocytes paid important role on the formulation of the response-to-injury hypothesis of atherosclerosis, which initially proposed that endothelial denudation was the fist step inatherosclerosis. It is reasonably deduced that these findings will leadto a novel therapeutic intervention to diabetic nephropathy by neutralizing CDllb/CD18 overexpression in peripheral blood PMN leukocytes in the diabetic patients. Although update researches have explored that CDllb/CD18 overexpression in peripheral blood PMN leukocytes is in the patients with diabetes mellitus, the relationship between CDllb/CD18 expression and the pathogenesis of microvascular complications in diabetes is unclear.We measured CDllb/CD18 expression in peripheral blood PMN leukocytes in patients with type 2 diabetes mellitus in different stages of diabetic nephropathy, in order to evaluate the association between the parameter of chronic inflammation and urinary albumin excretion and explore the possible role of chronic inflammation in the pathogenesis of diabetic nephropathy.Design and methods1. Subjects1.1 DM group: 86 patients of type 2 DM (male 52, female 34, age 59. 1 + 8. 2 years) who met the criteria of the WHO (1999) for diagnosis and classification of diabetes participated in the study. According to Mogensen' s principle, all type 2 diabetic patients were divided into three groups:(1)patients with normoalbuminuria(NA), urinary albumin excretion(UAE)<30mg/24h; (2)patients with microalbuminuria(MA),30mg/24h= |
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