Effects Of Shen Fu Injection On The Activity Of ATPase In The Hepatic Ischemia Reperfusion Injury In Rats

AIMTo investigate the effect of Shen Fu Injection on the activity of ATPase in the hepatic ischemia reperfusion injury in rats and explore its mecheanism.METHODSThirty-six male Wister rats were randomly divided into Shen Fu Injection-treated group(SF group) and physiological saline-treated group(NS group). After hepatic ischemia 15 minutes and reperfusion 1 hour, 3 hours and 24 hours, the hepatic tissue were resected respectively to determine the activity of ATPase and progress enzyme-histochemistry dyeing.RESULTSAfter 15 minutes ischemia and 1 hour reperfusion, the levels of Na+-K+-ATPase and Ca+-Mg+-ATPase in SF group were significantly higher than NS group(p<0.05). After 15 minutes ischemia and 3 hours reperfusion, the levels of Na+-K+-ATPase and Ca+-Mg+-ATPase in SF group were also significantly higher than NS group(p<0.05). But after 15 minutes ischemia and 24 hours reperfusion, the levels of Na+-K+-ATPase and Ca+-Mg+-ATPase in hepatic tissue were no significantly differences between the SF group and NS group(p>0.05).CONCLUSION...