The Study On Syndrome Differentiation Of Traditional Chinese Medicine Of Type 2 Diabetes Mellitus And The Associativity Of Insulin Resistance

Part one Literature ResearchThis research based on referring to domestic and international literature and observing the current research situation of type 2 diabetes mellitus insulin resistance, and mastered the cognition of etiology, pathogenesis, treatment of type 2 diabetes mellitus from the period of Huangdineijing to tang, song, yuan, ming, qing dynasty and the clinical experience of modem traditional Chinese physician. We also summarized the research method and achievements of improving type 2 diabetes mellitus insulin resistance in TCM for the past few years and provided solid theory support for clinical study. Part two Clinical Research1. Objective :To discuss the feature of TCM syndrome of type 2 diabetes mellitus and to provide scientific support for syndrome differentiation and treatment in clinical work.2.Method:We adopted retrospective investigation to registered the syndrome differentiation,age, course of disease, BMI, FPG, FINS, IAI, blood-fat and HbAlc etc of 150 cases . Theseconsequences had been related to TCM syndromes. Whereafter, we observed the regularityof distribution of TCM syndromes and the associativity of IR and these index.3.Result:(1)Among type 2 diabetes mellitus patients, syndrome of humid heat distressing spleen wasmaximum , then is syndrome of stagnation on liver and deficiency on spleen ,next issyndromes of yin deficiency, dryness-heat and blood stasis, and syndromes of deficiency onboth yin and yang were minimum.(2)The comparison of course of disease in all TCM syndromes showed that syndrome ofstagnation on liver and deficiency on spleen was the shortest one, the other three groupswere longer, between comparison there was a statistical significance( P<0.01).The course ofdisease of syndromes of deficiency on both yin and yang was longer than that of syndromeof humid heat distressing spleen and syndromes of yin deficiency, dryness-heat and bloodstasis, between comparison there was a statistical significance( P<0.01).(3)IAI of all TCM syndromes were lower than that of healthy control group(P<0.01),amongthe total IAI of syndrome of humid heat distressing spleen was lowest, in contrast withother three groups there was a statistical significance( P<0.01 或 P<0.05).(4)BMI, HbAlc of type 2 diabetes mellitus patients were also higher than that of healthycontrol group, and the contrast in all TCM syndromes showed that BMI, HbAlc ofsyndrome of humid heat distressing spleen were highest(P<0.01), there was no statisticalsignificance in comparison of other three groups.(5)The level of CHOL and TG was hightened by turns from healthy control group,syndromes of deficiency on both yin and yang, syndrome of stagnation on liver anddeficiency on spleen, syndromes of yin deficiency, dryness-heat and blood stasis tosyndrome of humid heat distressing spleen. The level of HDL-C was degraded by turnsfrom healthy control group, syndromes of deficiency on both yin and yang, syndromes ofyin deficiency, dryness-heat and blood stasis and syndrome of stagnation on liver anddeficiency on spleen to syndrome of humid heat distressing spleen. To compare syndromeof humid heat distressing spleen with all other syndromes showed that there was astatistical significance ( P<0.01)(6)There was negative correlation in comparing IAI with BMI, FPG, FINS, HbAlc, CHOLand TG(P<0.01).there was positive correlation in comparing IAI with HDL-C, and therewas not apparente associativity between IAI and age and course of disease.supplement: The clinical curative effect observation on 30 cases of type 2 diabetes mellitusinsulin resistance who were treated by the method of removing heat, promoting diuresis andnourishing spleen.l.objective:To observe the clinical effect on patients of type 2 diabetes mellitus insulinresistance which were treated by the method of removing heat, promoting diuresis andnourishing spleen, and to investigate it's action mechanism.2.Method: Based on using medicine of dropping sugar of sulfonylureas added decoction ofdanggui removing pain in patients who were selected .One month is a course of treatment,and they should be treated for one to two course of treatment continuously. Observed thechange of FPG, FINS, IAI, blood-fat and HbAlc of patients between before treatment andafter treatment.3.Result:(l)The result of clinical curative effect showed that among 30 cases better results were 5cases and good results were 21 cases, the total rate was 86.7%.(2)The result of improving IR showed that among 30 cases better results were 7 cases andgood results were 20 cases, the total rate was 90%.(3)After the treatment FPG and FINS degraded apparentely, the comparison between beforeand after treatment showed a statistical significance( P<0.01). IAI was raised apparentelyafter the treatment, the comparison between before and after treatment showed a statistical...