Clinical Study On Relationship Between TCM Differentiation Syndromes Of Type 2 Diabetes Mellitus And Insulin Resistance

CIinicaI Study on ReIationship Between TCM DifferentiationSyndromes of Type 2 Diabetes MeIlitus and insuIin resistanceMajor: lntegrated TraditionaI Chincscand Westcrn McdicinePostgraduatc: Wu XucpingTutor: Chicf Physician Zhou GuoyingABSTRACTBackgroud: Insulin resistance (IR) is the basic characteristic oftype 2 diabetes n1ellitus (DM,). IR. Lipide metabolisn1 disturbance andcytokine have been implicated in the chronic vascular complications ofDM,.Aim: To study the relatiOI1ship between the TCM syndromes andIR, and to study the reIationship between the TCM syndromes andchronic vascular complications (VC), whick provide i11dex fOr DM, andit' S' VC.Materials and Mcthods: According to WHO diagnosis criteria andTCM diJYerentiation criteria, We selected 83 cases (45 male and 38felPale): The average age is 56.32I l2.l7 years old: The process ofdisease is 8.52 I 6.43 years; 48 cases are vascular complications (VC),35 cases are non-vascular complications (NVC): TCM syndromsinclude Yin deficiency di1d l1eat excess syndl'ome (YOHES, 24). Qi andYin deficiency syndrome (QYDS, 4l) \ Yin and Yang deficiencysyndrome (YYDS,l8): of the 83 cases, 54 are blood stasis syndrome(BSS), 29 are non-blood stasis syndrome (NBSS).30 healthy people (l6male and l4 ttmale) were taken as the controI group, the average age isl55.73f l l .68 years old. We detected fastil1g plaslna glucose (FPG) byglucose oxidase, fasting insulin (F[ns) by chemiIuminescentinllllulloassay, triglyceride (TG) and l1igh density lipoprotein-cholesterol(HDL-C) by zymology, tumoT necrosis factor- Q (TNF- Q ) by enzymelinked immunosorbent assay (ELISA), thc reverse of tl1e product oI' FPGand Flns is used as the insulin sensitivity index (ISI), that is, lSl=l/FPGX FIns'RcsuIts: l' Comparcd witl1 tl1e control group, the lSI of DM, wassignilicantly 1ower (P<0.0l), the level of TG was higher (P<0.0l), thelevel of HDL-C was lower (P<0.0l), the level of TNF- a was higher(P<0.01). The process of disease of VC was longer than that of NVC(P<0.05), al1d other factors were lnore serious' 2. Tl1e lSl of TCMsyndromes were lower than tl1at of tl1e control group (P<0.0l ), the degreeof [R was as follow: YYDS>QYDS>YDHES, and the same fOllow as thechanges of the process of disease of the TCM syndromes (P<0.05,P<0.01 ): The level of TNF- Q \ TG were higher than that of the controlgroup (P<0.05, P<0.0l), tlle level of HDL-C was lowest ill YYDS(P<0.0l ). 3. Compared with NBSS, in BSS, the process of disease waslonger (P<0.0l), ISl was lower (P<0.0l), the level of TG. TNF- u werehigher (P<0.0 l ), the level of HDL-C was Iower (P<0.0l ). 4. There wassollle distribution of BSS il1 each TCM syndron1, and QYDS al1d YYOSwere higher than that in YDHES (P<0.05), there was no obviousdifference between QYDS and YYDS (P>0.05). 5. The ratio of VC in2QYDS and YYDS wer higher than that in YDHES (PO.05). 6. The occurance of VC in BSS was higher than that in NBSS (P