Antioxidative Effect Of Ipomoea Batatas Poir Cv Anthocyanins On Mice Irradiated By ～(60) Co Gamma Ray

Objective To investigate the anti-irradiation effect of Ipomoea Batatas Poir Cv anthocyanins on mice irradiated by ~60Co gamma ray in vivo. Methods We established the irradiation damage models of Kunming mice by ~60Co gamma ray (6.0 Gy, at a dose rate of 0.65Gy/min) in vivo. The mice were randomly divided into six groups, including control group and five ~60Co groups (model, low dose, middle dose, high dose Ipomoea Batatas Poir Cv anthocyanins and nilestriol positive control). We counted the white cells, calculated the spleen and thymus indices of the mice. We measured the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-px) and the amount of malondialdehyde (MDA) , reactive oxygen species (ROS) and total antioxidative capacity (T-AOC) of the mice. Furthermore we measured the formation of micronuclei and the mutation of chromosomes in mice. Results The results indicated that at the dose of 6.0Gy, Ipomoea Batatas Poir Cv anthocyanins could increase the spleen and thymus indices, inhibit the decrease of SOD, GSH-px activities and T-AOC and the increase of the amount of MDA and ROS of several organs in mice with dose dependent manner. But Ipomoea Batatas Poir Cv anthocyanins had no influence on the amount of white cells, the formation of micronuclei and the mutation of chromosomes. Conclusion Ipomoea Batatas Poir Cv anthocyanins has protective effects on mice irradiated by ~60Co in vivo. The mechanism might be attributed to its antioxidative capability and the modulation of the immune system.