Expression And Clinical Significance Of CyclinD₁ In Breast Cancer

Objective To investigate the expression of CyclinD₁ in breast cancer andevaluate its clinical significance, provide help to predict the prognosis and decide the choose of endocrine therapy.Material and Methods CyclinD₁ were measured in 78 cases of breast cancertissues and 37 cases of benign disease by immunohistochemistry SP method using monoclonal antibody to their protein.Results The positive rate of CyclinD₁ in breast cancer in different pathologicstage were 47.62%(G₁),61.76%(G₂) and 17.39%(G₃) respectively. In benign disease they were 6/17 (35.29%, atypical ductal hyperplasia) and1/20 (5.00%,common breast disease) .There was difference of CyclinD₁ between breast cancer and benign disease even the different pathologic stage. The expression of CyclinD₁in breast cancer was significantly higher than that in benign disease. Their expression was not related to gender, position, clinical stage, lymph node metastasis and tumor sides of the disease (P>0.05), but related to pathologic stage (P<0.01). Analysis the relationship of CyclinD₁and estrogen receptor (ER), the positive rate of CyclinD₁ in ER (+) tissue is higher than ER(-) tissue(P<0.05). Compare the groups of CyclinD₁ (+) ER ( + ) and CyclinD₁ ( + ) ER (-), X²=7.159, P<0.01, the difference is significant.Conclusion1 Overexpression of CyclinD₁ may play an important role with differentiation and development of tumor. The expression of CyclinD₁in breast cancer was related to pathologic stage.2 The high expression of CyclinD₁ protein and positive expression of ER is highly identical in breast cancer. Its expression may be helpful to evaluate the response to endocrine therapy.