| Objective To investigative the changes of TXB2,6-Keto-PGF1a,NO,ROS incoronary heart disease(CHD) with qi-deficiency and blood stasis syndromeand the mechanisms of the fuyuan capsule effect on the changes. Methods In the term of the criteria of our absorbable CHD and qi-deficiencyandblood stasis syndrome,we chose objectively and strictly 42 patientssuffering from CHD with qi-deficiency and blood stasis syndrome .Amongthem, 24 cases,as treated group, were given the fuyuan capsule to takeorally(mean age=56.28±4.42, n=24), the others , as control group,weren't given any medcine(mean age=55±4.28,n=18). Beside, we alsoestablish healthy control group(mean age=27.65±3.31,n=14). Patientsof CHD are admitted into our study objects who must be in accord withlow ,middle ,serious degresses on the base of the criterion of namingischemic cardiomyopathy and diagnosis , the criterion is constituted by theinternational congress of Cardiology and WHO for clinical naming CHD bymeans of standards method in 1981.among CHD , but except the patientssuffering from serious brain or liver or kidney or so on diseases. Accordingto the criterion of qi-deficiency among all deficiency syndromes in May of1986 as well as the criterion of blood stasis syndrome in October of 1988,Patients of qi-deficiency and blood stasis syndrome are admitted into ourstudy objects who must be both in accord with above 7 scores inqi-deficiency syndrome and in accord with above 5 scores in blood stasissyndrome, but except the patients suffering from serious brain or liver orkidney or so on diseases. The level of NO and ROS in blood serum weremeasured by the chromatomery; The level of TXB2 and 6-Keto-PGF1a inblood were measured by ARI. We compared variations of TXB2,6-Keto-PGF1a, NO ,ROS and blood viscosity among three groups . Besides,We also observed the effects of the fuyuan capsule on the level of TXB2and 6-Keto-PGF1a and blood viscosity in blood . Results The levels of TXB2 and ROS in the group suffering from CHD withqi-deficiencyand blood stasis syndrome were significantly higher than thosein healthy control group(P<0.01), but The levels of 6-Keto-PGF1a and NOin the group suffering from CHD with qi-deficiency and blood stasissyndrome were significantly lower than those in healthy control group(P<0.01). (2) There were significantly negative correlations between thelevels of TXB2 and 6-Keto-PGF1a in blood serum or TXB2 and NO inblood serum(P<0.01); however , There were significantly positivecorrelations between the levels of TXB2 and ROS(P<0.01).(3)The bloodviscosities of groups suffering from CHD with qi-deficiencyand bloodstasis syndrome seemed to be increased higher than those of healthy controlgroup(P<0.01);and their blood were in the chaotic states of high-density ,high-viscosity, high-concretion and high-cohesion(P<0.01). There weresignificantly positive correlations between the blood viscosity and TXB2,ROS(P<0.01); conversely, there were significantly negatively correlationsbetween the blood viscosity and 6-Keto-PGF1a or NO(P<0.01).(5) In testgroup, they were given to take fuyuan capsules orally every day and hadbeen taken fuyuan capsules for two months ;After two months , we can findout the fact that their levels of TXB2 and ROS in blood dramaticallydropped (P<0.01),but their levels of TXB2 and ROS were still higher thelevels of healthy control group(P>0.01) ; meantime , we can also find outanother fact that their levels of 6-Keto-PGF1a and NO in blood remarkablyincreased(P<0.01), but their levels of 6-Keto-PGF1a and NO were stilllower the levels of healthy control group(P>0.01).(6)In test group, theyconsistently had been taken the fuyuan capsules orally for two months andwe can seem to the phenomenon that their boood viscosities weresignificantly lower(P<0.01),but above thelevels of healthy control group(P>0.01). Conclusions ( 1 ) The ratio of 6-Keto-PGF1a /TXB took place seriouslymaladjustment , 6-Keto-PGF1a level markedly decreased , but TXB2 levelremarkablely increased; as well as NO level significantly dropped in bloodfrom group who w...
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