Elevated Serum Levels Of MMP-9,Endostatin And VEGF In Lung Cancer And Its Clinical Significance

Objective To study the relationship among serum levels of MMP-9, endostatin, VEGF and the clinical pathophysiological characteristics in lung cancer patients.Methods Serum levels of MMP-9, endostatin and VEGF weredetected in 144 patients with lung cancer and 56 patients with benign pulmonary disease, compared with those of 52 cases in healthy group by ELISA method.Results (l)The serum levels of MMP-9, endostatin and VEGF inpretreatment lung cancer patients (678.06±38.79ng/ml,124.90±3.33 ng/ml and 809.81±129.43pg/ml) were significantly higher than those in patients with benign pulmonary diseases (228.96±15.39ng/ml,91.43±4.44ng/ml and 490.14±14.58pg/ml,P<0.007) and healthy group(90.07±13.55 ng/ml ,61.01±5.15ng/ml and 368.68±5.82pg/ml, P<0.001). (2)The serum levels of MMP-9, endostatin and VEGF in pretreatment lung cancer...