The Detection And Meaning Of Plasma Adiponectin And TNF-α In Nondiabetic First-degree Relatives Of Type 2 Diabetes

Objecctive This study was aimed to determine whether nondiabetic first-degree relatives (FDR) of type 2 diabetic subjects differ in insulin resistance(IR), serum adiponectin and tumor necrosis factor- α (TNF- α )from control subjects without a family history of diabetes, whether adiponectin is related to IR and body mass index (BMI) and TNF- α . METHODS The study was carried out in 39 subjects with type 2 diabetes, 40 nondiabetic FDR of type 2 diabetic subjects and 38 control subjects who were similar for age, sex, and BMI. The levels of plasma adiponectin and TNF- α concentrations were analyzed in nondiabetic subjects with and without familiay history of type 2 diabete and type 2 diabetic subjects. All parameters were analyzed by SPSS 10.0 software. Result (1) Plasma levels of adiponectin in the diabetic subjects were lower than those in nondiabetic subjects, P<0.05, while the levels of triglycerides, fasting insulin, HOMA-IR and TNF-α are higher than nondiabetic subjects, all P<0.05 . However, FDR of subjects with type 2 diabetes and those without a family history of diabetes had comparable levels of adiponectin and TNF- α . HOMA-IR was higher in nondiabetic FDR of type 2 diabetic subjects. (2) Inverse correlations were observed between adiponectin levels and BMI (r=-0.43, P<0.01), WHR (r=-0.24, P<0.01), HOMA-IR (r=-0.24, P<0.05) and TG (r=-0.33, P<0.01) .TNF-α was positively related to HOMA-IR (r = 0.297), FBG(r = 0.369) , all P<0.01. HOMA-IR was positively related to BMI, WHR, TG(r = 0.238, r = 0.214, r = 0.226, P<0.05) and FBG(r =-0.63, P<0.001). (3) In multivariate analysis, BMI, serum triglyceride concentration, plasma insulin and HOMA-IR remained significantly related to plasma adiponectin concentrations. FBG and BMI remained significantly related to TNF- α. Conclusion (1)Adiponectin concentrations were decreased in type 2 diabetic subjects and obese subjects. (2) The FDR of type 2 diabetic subjects have no differentce in adiponcectin concentrations and TNF-α from control subjects without a family...