Epidemiological Study On HBV Intrauterine Infection

Objective To explore hepatitis B virus (HBV) carrying rate among pregnant women and HBV intrauterine infection rate in neonates of HBV carrying pregnant women, and to study the risk factors of HBV intrauterine infection and to study the effect of HBV intrauterine infection on the development of neonates. Methods Serological HBV markers were test by ELISA among pregnant women under routine examination before delivery. HBV carrying pregnant women were screened as target population. After delivery, umbilical bloods of neonates were tested, the weight, body length, head circumference and chest circumference of the neonates were measured. Neonates with HBV by intrauterine infection were selected as cases, while the rest as controls, so as to analyze the risk factors of intrauterine infection. HBV intrauterine infection rate among pregnant women with and without HBIG inoculation was compared to analyze the effect of HBIG inoculation. Growth statuses of 112 neonates were evaluated using Z scores. Results Total of 3415 pregnant women were tested in Hefei city from 2002 to 2004, and HBV carryingrate was 3.34% (114/3415) . Significant difference was found between pregnant women in the city (2.91%) and those in countryside (5.62%) (x~2 =9.23, P<0.01) . 33 of 112 neonates were infected with HBV (29.46%). There was no significant difference in Z scores of W/A (t=0.21,P=0.832), H/A (t=1.60,P=0.122), head circumference (t=1.03,P=0.311) and chest circumference (t=0.89,P=0.372) of neonates between two groups. Univariate analysis revealed that ORs of positive of HBeAg, history of vagina bleeding, history of abdominal pain, hepatic function of the mother, pattern of delivery, gender of neonates and contamination of amniotic fluid were 2.56(1.05-6.22), 3.29(0.93-7.69), 1.84 (0.54-6.27), 0.64(0.27-1.52), 1.38(0.61-3.13), 0.69 (0.30-1.56) and 1.79(0.76-4.24) respectively. Multivariate unconditional logistics...