The Effect Of Different Anesthetics On The Hemodynamics And NO/ET In Patient With OSAS During Induction

Objective:We studied the effects of the different intravenous anesthetics on the hemodynamics and the plasma levels of nitric oxide (NO) and endothelin(ET) in medium or severe obstructive sleep apnea syndrome(OSAS) patients induced by stress response to tracheal intubation, in order to find the best intravenous induction agent for the OSAS patients, and provide the theoretical warranty for clinical anesthesia.Method:40 selected medium or severe OSAS patients undergoing uvulopalatopharyngoplasty (UPPP),were randomly divided into 4groups (n=10):A group(N.S group), B group(midozolam), C group(propofol),D group(etomidate). In A B C D group anesthesia was induced with 0.9%NaCl 2ml or midozolam 0.05mg/kg, fentanyl 1 μg/kg or propofol 0.5mg/kg, fentanyl 1μg/kg or etomidate 1mg/kg, fentanyl 1μg/kg .We recorded SBP DBP, HR and Sp02of all patientis before induction(T,), 3 min after induction (T2),at intubation (T3) and 3min after intubation(T4), respectively. Blood samples were taken at the same time as above for determination of plasma levels of NO and ET, NO/ET ratio was calculated. Venus blood of 10 healthy persons were colleted as normal control (E group).Result:1. In OSAS patients, SBP, DBP and ET was higher, while NO level and NO/ET was lower than those of healthy person.