| Objective: To explore the mechanism of electro-acupuncture effect on senile dementia rat's learning and memory function.Methods: Divide senile dementia AD rats into normal control group, sham-operation group, model group and electro-acupuncture group randomly, adopt D-galactoside combined aluminum chloride and Scopolamine damage model, treat Baihui, Dazhui, Taixi and Zusanli with electro-acupuncture. Use biochemical method to observe the effect of electro-acupuncture on AchE of senile dementia AD rat's brain tissue; use optical and electron microscope to observe morphosis change of rat's brain tissue; use step-down test to observe rat latency and mistake times, to understand it's learning and memory ability.Results: Electro-acupuncture can decrease AchE ability of VD rat's brain tissue evidently; Electro-acupuncture can increase learning and memory ability of rat ; Electro-acupuncture can influence morphosis in hippocampal synapse. Electro-acupuncture can decrease AD rat latency in step-down test, improve AD rat learning and memory in some extent. Electro-acupuncture is a simple and effective method for treating AD. |
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