Pharmaceutical Study On Yaobao Anti-Cancer Granule

Compound Yaobao Anti-cancer granule is a new prescription of Traditional Chinese Medicine, which consists of 17 herbs such as herba Radix Sophorae Tokinensis, herba Rhizoma Fagopyri Dibotryis, herba Caulis Mahoniae, herba Rhizoma Curydalis, herba Bulbus Firtillariae Cirrhosae, ect. Therefore it can be chiefly used to treat malignant tumors. With the guidance of the theories of Traditional Chinese Medicine Yaobao Anti-cancer granule was studied with modern pharmaceutical technology. On the basis of effective components and parts as well as the characters of components of the herbs, traditional decoction was transformed into granules by different extractions.This research mainly studied on the preparing technique of Yaobao Anti-cancer granules. The technology of optimum extraction, alcohol-precipitate and preparation moulding were selected by using orthogonal design which used quite a few assessing norms to evaluate them comprehensively. The research of extraction was to select conditioned parameter of water-extract technique, conditioned parameter of alcohol-extract technique and conditioned parameter of animal pharmaceutical-extract technique. Meanwhile middle test enlargement and quality standard were finished. The content of matrine in herba Radix Sophorae Tokinensis was determined by HPLC. Moreover the research used TLC to identify herba Radix Sophorae Tokinensis, herba Rhizoma Fagopyri Dibotryis, herba Caulis Mahoniae, herba Rhizoma Curydalis and herba Bulbus Firtillariae Cirrhosae. Then the preliminary stability was fulfilled on the basis of controllable quality standard.The results indicated that the technique of preparation was reasonable and practical, the standard of quality was controllable and the quality of the sample was steady as well. The results of this study can establish stable foundation for developing new...