The Role Of Soluble Platelet Membrane Glycoprotein V In Coronary Heart Disease

Objective:The study sought to explore the of soluble platelet membrane glycoprotein V (sGPV) expressed in coronary heart disease(CHD). Meanwhile,the value of sGPV was estimated in platelet activation by shear stress by comparing with soluble P-selection (sPs) which can reflex platelet activation. At the same time, the study sought to explore the correlation of sGPV levels and stenosis degree of coronary artery.Methods:73 patients with coronary disease admitted in our hospital from October 2003 to Febrary 2005 were devided into three group: angina, unstable angina and acute myocardial infarction. 31 healthy people as controls were enrolled. The plasma in angina and controls were obtained at hospitalization.The plasma in unstable angina were obtained at hospitalization, 3 days after oraling clopidogrel, 3 days after percutaneous coronary intervention (PCI). The plasma in acute myocardial were obtained before PCI and 3 days after PCT. The sGPV levels were measured by ELISA.Results: l.SGPV levels were significantly higher in patients with CHD, while no significant difference was found either in patients with CHD. The levels were significantly lower in patients with UA, AMI after PCI. 2. Asignificant correlation was observed between sGPV levels and stenosis degree of coronary artery.Conclusion: 1.No significant difference was found in shear stress with CHD. 2 .Platelet activation by shear stress played important role CHD.3. Asignificant correlation was observed between sGPV levels and stenosis degree of coronary artery.