Study On Design And Implementation Of Steep Pulse System For Tumor Treatment Based On Digital Signal Processor

It has been validated that cell membrane electroporation, including reversible and irreversible electropermeabilization occurred, when it was exposed to high intensity electric pulse. And the electroporation degree has relation to many pulse characteristic parameters. For deeper research on the inner inter-mechanism of electric pulse and cell membrane, it's essentially to develope a set of high voltage steep pulse tumor treatment system, whose parameters can be set agilely, exported stably, monitored conveniently.This paper brings forward a pulse parameters controlling and measuring integrative scheme based on Digital Signal Processor. The high voltage steep pulse tumor treatment system, designed and realized combining Complex Programmable Logic Device and other electrical components, not only can on-line monitor the parameters of pulse rise time, fall time, repeat frequencies and pulse durations, et al, but also can close-loop control partial parameters fore mentioned. The paper detailedly introduces the primary principles of PWM controlling and the concretes method of frequency difference multiply, briefly illustrates the control strategy of Liquid Crystal Display module, real time clock module and the capacitor switching circuit, particularly discusses the scheme and the function of the voltage measurement module, the rise time and fall time measurement module, the voltage amplitude controlling module and the keyboard interface circuit, the RS-232 communication module. Moreover, the simulation processes and results of voltage amplitude measurement module and rise time/fall time measurement are recommended in this paper. The classic foreground and background pattern is chosen as the software organizing form in this paper, in which the main program is background application and the interrupt service program is background correspondingly. By switching the foreground and background program instantly, sorting priority of applications, the soft can respond a series task of measurement, controlment and display instantly.Including the adjustment and test to measurement module, controlment module and display module, the paper accomplishes the adjustment and test to the whole high voltage steep pulse tumor treatment system. The test results indicate that the design scheme and the realization method brought forward in this paper can satisfy the requirements of tumor cell irreversible mechanism research and clinic application, obtaining the anticipated target.