| Ovarian cancer is the second in genital system , and it's death rate is thefirst in gynecological tumor. Epithelial ovarian tumor is common in primarilymalignant tumor. The clinical characters of early Ovarian tumors is obviouslydifferent with the late tumors, and it's prognosis is better, moreover five yearsof survival rate is more than 90 percent. Recent years it's incidence isgradually increasing, consequently early diagnosis is the key point ofprolonging the patients'life span.COX-2,a representative gene of quicktransient early response, can be induced quickly ,therefore it should beregulated strictly.COX-2 expression can be induced by exterior and interiorextensive excitation of cell such as VEGF.VEGF ,a high degree of specificitygene which can prompt blood vessel generate, is the most important ininducing neovascularity. Growth, infiltration and metastasis of entity tumordepends on nutrition of new vessels, consequently vascularization is the mostimportant factor in development of entity tumor, which makes a direct impacton the prognosis of tumor. Up to now researches have been carried out fromdifferent angles. Our study investigates the expression of COX-2 and VEGF inepithelium ovarian cancer ,and compares among serous cystadenoma,boundary cystoadenoma and cystadenocarcinoma, and explores originaltargets of biochemical modification in process of epithelium ovarian cancer,thus it will provide theory for clinical differential diagnosis and treatment.Our study collects the operative specimen of pathodepartment in the secondclinical hospital of Jilin University from July 2002 to 2003.The number ofepithelial tumor of ovary is 93.Among them malignant neoplasticdiseases :serous cystadenoma (13), boundary cystadenoma (10),cystadenocarcinoma(70).According to WHO classify standard:well-differentiated(30), moderately differentiated(30),poorly differentiated(27).Pathostaging (according to FIGO standard): â… ,â…¡stage (12), â…¢,â…£stage(58).Lymphatic metastasis (24),no lymphatic metastasis(46),age(28-75).COX-2and VEGF expression in three groups is detected by rule SP two footworks.Experimental data is analysed by SPSS and X2 test. Our finding indicates that COX-2 expression masculine rate is 23.08% ininnocence Serous cystadenoma, 40% in boundary cystoadenoma, and 60%incystadenocarcinoma. Comparing with the two former there is nosignificance(p>0.05, X2=0.765),and the last two is the same (p>0.05,X2=1.432).Comparing the first with the third there is significance (p<0.05,X2=6.022).All above illustrates that COX-2 expression rate and relativeamount in epithelium ovarian cancer is higher than innocence ovarian Serouscystadenoma and boundary cystoadenoma. VEGF expression rate is 23.08% ininnocence Serous cystadenoma, 70% in boundary cystoadenoma, and 74%incystadenocarcinoma. Comparing with the three there issignificance(p<0.05),and it's expression rate is gradually increasing, whichillustrates that there is significance among them. Our study still acquire that VEGF masculine expression is 38 in 49 casesof COX-2 masculine expression(77.8%), VEGF masculine expression is24 in44cases of COX-2 negative expression(54.5%).Comparing with them there issignificance (p<0.05, X2=5.52).In pathoclass of epithelium ovarian cancerCOX-2 masculine expression rate : well-differentiated(46.1%), moderatelydifferentiated(60%), poorly differentiated(44.4%).Comparing with them thereis no significance (p>0.05, X2=1.15).VEGF masculine expression rate amongthem : 30.8%,66.7%,51.8%.Comparing with them there is nosignificance(p>0.05, X2=5.08).In clinical stage COX-2 masculine expressionrate :earlier period (â… ,â…¡)16.7%,advanced stage(â…¢,â…£)58.7%.Comparingwith them there is significance(p<0.05, X2=7.01).VEGF expression rate :earlier period (â… ,â…¡)8%,advanced stage(â…¢,â…£)49.1%.Comparing with themthere is significance(p<0.05, X2=6.54).Our experimental result demonstratesthat COX-2 and VEGF expression is significant in clinical stage of epitheliumovarian cancer, and it becomes higher following the stage increasing. In noduslymphaticus metastasis COX-2 expression rate: metastasis(38%), nometastasis(15.2%). Comparing with them there is no significance(p>0.05,X2=0.095).VEGF expression rate: metastasis(28%), no metastasis(56%).Comparing with them there is significance(p<0.05, X2=4.74).It illustrates thatVEGF expression becomes higher following lymph metastasis in epitheliumovarian cancer.Our study discovers that COX-2 expression is not concerned with FIGOStaging, patho-class,and histology type.COX-2 expression and relative amountin serous cystadenoma is higher than innocence and boundarycystadenoma(p<0.05),which indicates that COX-2 is possibly important ingeneration of serous cystadenocarcinoma. In clinical stage COX-2 expressionand relative amount is higher in advanced stage than earlierperiod(p<0.05).COX-2 expression has positive correlation with ovarianepithelium carcinogenesis. VEGF expression in serous cystadenoma, boundarycystadenoma,and cystadenocarcinoma is progressive, and there is significanceamong them(p<0.05). VEGF expression in lymphoid node metastasis there issignificance (p<0.05). VEGF expression in patho-class there is no significance(p>0.05).Our study discovers that blood vessel positive growth factor isimportant in tumorous growth ,development metastasis. Most entity tumorsproduce a lot of VEGF, which induces Vascularization, and thereforestimulates metastasis.COX-2 gene expression ,not detected in many normaltissues, enerates through induction of cytokine ,growth factor ,oncogenes ,and... |
PDF Full Text Request