Significance Of Vascular Endothelial Growth Factor And Microvessel Vascular Density In Pituitary Adenomas

Objective Pituitary adenoma is a kind of multiple encephalic tumor , which account for 10%~20% in all encephalic tumors .Pituitary adenomas are benign tumors on histologically , but about 30%~40% of them are invasive , which can not be differentiated by routine histological methods . The subjects investingated are pituitary adenomas which were resected from patients in past three years . We use them to analyse the relationship between vascular endothelial growth factor (VEGF) protein , microvessel density (MVD) and invasive pituitary adenoma . By VEGF protein and MVD , we can determine whether those pituitary tumors are invasive . And they can offer some reference in postoperative monitors and adjuvant treatments (including common radiotherapy , stereodirected radiotherapy and medication etc.).Methods We collected 42 samples , each of them were cut into half . One part was used to detect the expression of VEGF by RT-PCR , the other was used to detect the expression of MVD by CD34 immunohistochemistry technique . Thus we can analyse the relationship between both the expression of VEGF and MVD and the invasiveness of pituitary tumor to cavernous sinus .Result Both the expression of VEGF and MVD in the cavernous sinus invasive pituitary adenoma was obviously higher than those in non-invasive pituitaryadenomas (p<0.05).Conclusion Both the expression of VEGF protein and MVD was highly correlated with the invasiveness of pituitary adenoma , and they can offer some important reference in the invasiveness of pituitary adenoma , the forecast of pituitary adenoma relapse , the postoperative treatments and prognosis .