Expression And Significance Of Skp2 And P27～(kip1) In Pathological Scar

Objective:To study the expression of Skp2 gene (s - phase kinase associated protein 2) in the pathological scars and its relation - ship with P27^kip1 level and to investigate its role and its probable mechanism in the pathogenesis of abnormal scars.Methods:Immunohistochemiscal techuique was performered to detect the expression and distribution of Skp2 and P27^kip1 cases protein in hypertrophic scar (42 cases), keloid (18 cases), normal scar (40) and normal skin (50 cases), statistics was used to analyze the data .Results:The positive rate of Skp2 and P27^kip1 protein expression was not statistically defferent between the hypertrophic scar and keloid (P>0.05), while they were all remarkably significant in comparison between normal scar and abnormal scar (P<0.05).In pathological scar the protein of Skp2 and P27^kip1 Showed a strong inverse correlation (P=0.004).Conclusion:The result indicated that the expression of Skp2 was increased and it may lead to decrease P27^kip1 level in the hypertrophic scar and keloid , Skp2 overexpression might play an important role in the proliferation of fibroblasts and in the pathogenesis of pathological scar by adjusting the regulation of cyclins such as P27^kip1.