| Objective To study the effect of octylphenol (OP) on reproductive ability of female rats and their offpring by ingestion before mating. Methods 50 female rats were randomly devided into five group. They were exposed to OP by gavage every other day at the dose of 600, 300, 150mg/kg respectively before mating. Corn oil and 30p.g/kg diethylstilbestrol were given to the control and positive group respectively. After 60 days, they were copulated to healthy male rats for three day and delivered naturally. The reproductive action was observed and the birth weights of offspring were measured. Mather and daughter rats were put to death after ablactation. Then the 40-day son rats were put to death. Results The female's estrous cyclicity became longer compared to the control group and the number of offspring per cote decreased with the increase of the dose. The average birth weights in 300mg/kg and 600mg/kg groups decreased significantly compared to the control group (P<0.05 and P <0.01) . PCNA increased in the uterus of prepubertal female offspring. Vimentin and T decreased in the testis of male offspring. In Coment Assay, DNA of testis was damaged in prepubertal male offspring. Conclusion In the test dose, the gavage ofOP before mating not only effects the mother' production ability butalso does to offspring.
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