Plasma Lysophosphatidic Acid And Associate Phospholipid In Coronary Heart Disease

Lysophosphatidic acid (LPA) and it's Associate phospholipid (AP) are a kind of phospholipids messenger which have the biology activity and produced by activated platelets. It could act as hormones and growth factors. And it could also influent the information transfer among cells and the growth, proliferation and differentiation of the cells, which would induce many vascular reactions such as the accumulation of platelets, the contraction of vascular smooth muscles and the proliferation of vascular smooth muscles. So it is considered that the LPA may be correlated with the development of cardiovascular diseases. The purpose of this article is to study the change of LPA/AP in 77 patients who received angiography and the relationship with coronary artery score (CAS). Objective:To investigate the change of LPA and Ap in coronary heart disease and their correlation with CAS.Methods:According to clinical syndrome and angiography, 43 patients were enrolled as acute coronary syndrome(ACS) group, 17 patients as stable coronary heart disease(SCHD) group and 17 non-CHD patients as control group. All the patients above were excluding infections and other inflammatory disease. Serum levels of LPA/AP were measured according to the kit directions and that of LDL and HDL ware measured on Olympus AU2700 analyser. The severity of coronary artery lesions was analysed by quantitive computer system(QCA) to acquire coronary artery score.The analyses were performed by using SPSS Professional Statistics 10.0. Statistical significance was defined as P<0.05. Results:1. Sex, hypertension and diabetes have little influence on the level of LPA/AP.2.Compared with control group, the levels of serum LPA/AP were significantly higher in CHD group(LPA:2.855±0.36umol/L vs 2.34±0.36umol/L, AP: 356.23±29.18 umol/L vs 297.88±45.90 umol/L, P<0.01).3. There were no obvious difference of LPA/AP between ACS and ACHD group (P>0.05).4. The levels of serum LPA were positively correlated with CAS(r=0.366, P=0.001)andAP(r=0.535, P=0.000).Conclusion:The increasing level of serum LPA/AP is correlated with CHD. Sex, hypertension, diabetes and smoking have no obvious influence on LPA/AP. So, LPA/AP could be regarded as a predict index of CHD and the progression of Coronary artery arterosclerosis: Severity.