The Correlation Between Expression Of HPSE And Proliferation, Invision, Metastasis And Angiogenesis In Pancreatic Cancer

Objective: To study the expression of heparanase( HPSE ) in pancreastic cancer and the correlation between HPSE and pancreatic cancerlocal proliferation, invasion, metastasis and angiogenesis.Methods: The expression of HPSE protein in 47 cases of pancreatic cancer, 24 adjacent tissues of cancer and 10 normal tissues was tested by immunohistochemical PV6000 method. In addition to that, the CD34 and proliferating cell nuclear antigen (PCNA) were also detennined by immunohistochemic stining, and then the assciation of the HPSE expression with microvessel density (MVD) and extent of proliferation of pancreatic carcinomas was analysed.Results: The rate of expression of HPSE protein in 47 cases of pancreatic cancer tissues (59.6%, 28/47) was significantly higher than that in adjacent tissues of cancer (20.8%, 5/24 )and normal tissues( 2/10 )(x~2=9.59,5.18;P<0.05). It was shown that HPSE protein expression did significantly not correlate with the size and histological grade of pancreatic cancer (x~2=2.52,2.18, P>0.05), but it correlated with the invasion, metastasis and survival time of the patients ( x~2=5.52,9.25,6.19, P<0.05) . The expression of HPSE protein was positively associated with the MVD and extent of proliferation of pancreatic carcinomas (r=0.586,0.594;t=4.9, x~2=15.11;P<0.05) .Conclusions: The expression of HPSE protein may play an important role in the growth, invasion, metastasis and angiogenesis of pancreatic cancer. Pancreatic cancer with a high proliferating activity tends to express HPSE. HPSE may be a valuable marker to evaluate biological behavior and prognosis of pancreastic cancer.