Expression Of Elf-1 And Rb In Several Epidermal Tumors And Its Significance

Objective The aim of the study was to investigate the expression of Elf-1 and Rb protein in several epidermal tumors and to study their relationship during the genesis of several epidermai tumors the skin and its significance. Methods Immunohistochemically method was used to detect the expression of Elf-1 and Rb in 75 specimens with squamous cell carcinoma (SCC), 15 specimens with basal cell carcinoma (BCC),12 specimens with Bowen's disease (BD),16 specimens with seborrheic keratosis (SK) and 10 specimens of normal skin tissues.Results In normal skin tissues, SK, BCC, BD and SCC,the positive rates of Elf-1 and Rb were significantly different,respectively( x~2 =46.87and 11.21, respectively,P <0.05). The positive rates were significantly different between the normal skin tissues,SK and BCC,BD,SCC,respectively( x~2 =9.64, 9.30, 29.88, respectively ,P <0.05). In SCC the expressive intensity of Elf-1 in different histopathological grade was significantly different x~2 =26.76, Hc =30.12, P均<0.05). The differences of Rb positive rates between the normal skin tissues,SK and BCC,BD,SCC were all obviously significant ( x~2 =4.17, 5.39, 6.84, respectively P <0.05) . The expressive intensity of of Rb protein in the normal skin tissues, BD and SCC were all obviously significant (Hc =46.54, 36.60, . respectively, P <0.05). But the positive rates or expressive intensity of Elf-1 and Rb was not significant between the normal skin tissues and SK, and no significance between BCC. BD, SCC, too. In SCC the expressive intensity of Elf-1 in different histopathological grade was not significantly different and no correlation was found between the expressive intensity of Elf-1 and Rb.Conclusion Overexpression of Elf-1 and loss of Rb protein expression may contribute to the genesis of. epidermal tumors . No correlation was found between the expressive intensity of Elf-1 and Rb in SCC. The expression of Elf-1 and Rb protein were not significantly different in several epidermal malignant tumor. Detection of Elf-1 and Rb proteins expression may be useful for early diagnosis.