The Changes Of Erythrocyte Innate Immune Function In Patients With Obstructive Sleep Apnea-hypopnea Syndrome

Objectives: To investigate the possible impact on erythrocyte innate immune function in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods: Complement receptor type 1 on erythrocyte(ECRl) in the fresh peripheral blood was detected in OSAHS patients and healthy controls by Guo-Feng's methods and FCM technique respectively. The detection of red blood cells immune functions includes the rossett rate of red-cell C3b receptors(RBC-C3bRR), red-cell immune complex(RBC-ICR) and the expression level of erythrocyte CD35.Results: Compared with the control group, OSAHS patients' levels of RBC-C3bRR and ECD35 were significantly lower (P<0.01,P<0.01), but the levels of RBC-ICR was significantly higher(P<0.001). And in patients with OSAHS, RBC-C3bRR levels correlated significantly with the AHI, MSaO₂, LSaO₂ (r=-0.44,0.401,0.448,P<0.01,0.05,0.01), the RBC-ICR levels correlated significantly with the AHI, MSaO₂, LSaO₂ (r=0.45,-0.438,-0.485, P<0.01,0.05,0.01), ECD35 levels correlated significantly with the AHI,MSaO₂,LSaO₂ (r=-0.442, 0.383,0.542,P<0.01,0.05,0.01).Conclusions: OSAHS patients exist impairment of the erythrocyte innate immunefunction, which may be caused by hypoxia.