Expression And Significance Of MUC1 In Vulvar Squamous Cell Carcinoma

【Objective】MUC1 is a high molecular weight transmembrane glycoprotein. High levels of MUC1 expression are associated with a poor prognosis of malignant tumor, such as cancers of the breast, ovary, pancreas, prostate, stomach and colon, esophagus, pharynx, larynx, eyelid and oral mucosa. However, little is known about the differences in MUC-1 oncogene expression among normal, benign, and malignant vulvar tissues. it remains unknown whether it plays a role in either an early stage of carcinogesis is or a later stage. To clarify the role of MUC1 in vulvar carcinogenesis through examination of its expression in a spectrum of vulvar lesions ranging from nonneoplastic epithelial disorders of vulvar,vulvar intraepithelial neoplasia (VIN) to vulvar squamouscel carcinomas( VSCC) and to analyze the relationship between MUC1 expression and clinical pathologic features of vulvar squamous carcinomas...