The Expression Of IGF-I In Human Glioma And Its Relationship With Cell Proliferation And Apoptosis

Objective : To explore Insulin-like Growth Factor I (IGF-I) expression in human glioma and the relationship between its expression and the expression of Ki-67 antigen ,Bcl-2 protein.Methods : Expression of IGF-I , Ki-67 and Bcl-2 were assessed by immunohistochemistry staining in 45 cases of gliomas and 10 normal brain tissues.Results : IGF-I was hardly expressed in all normal brain tissues , while its expression rate was 71.1%(32/45) in 45 cases of gliomas. We found there was a significant difference between low grade(WHO â… ~â…¡) and high grade(WHO â…¢~â…£) of gliomas(p<0.05). We also showed that the expression of IGF-I increased by Ki-67 (P <0.01, r_s=0.732) and Bcl-2 (P<0.01, r_s=0.698) expression rising.Conclusion : Acting as a mitotic factor of glial cells, IGF-I is expressed highly with the malignant level of gliomas increasing. So it suggests that IGF-I can be used as an index of proliferation ability of glial cells. IGF-I and Bcl-2 may play a combined role in the inhibitted apoptosis of glioma cells, both are associated with the pathogenesis and development of glioma.