Effects Of Meihualubianjing On Oligospermia And Asthenospermia In Rats

Objective To study the curative effects of Chinese herbmeihualubianjing capsule on oligospermia and asthenospermia andanalyze its mechanism.Methods Forty-five super Wistar mature male rats wererandomly divided into five groups: the normal control (five), themodel control (ten), the treatment group by lower dose (ten), thetreatment group by higher dose (ten), the treatment group byclomifene (ten). Except for the normal group, all the other four groupswere lavaged with GTW (20mg/kg) once a day for thirty days, so weestablished animal infertility models of rats. Then the treatment groupby higher and lower dose were perfused with meihualubianjing once aday for thirty days, the higher dose is 2g/kg, the lower dose is 1g/kg.The treatment group by clomifene were perfused with clomifene oncea day for thirty days, the dose is 5mg/kg. Then all the rats were killed,serum were separated from blood, semen were imbibed from tail ofepididymis, Pathological histological examination was performed onthe testis. Then we compared the improvements of general seminalparameters, the level of hebin in serum, and the histological change oftestis before and after treatment.Results â‘  Compared to model group, small and large-dose groups hadsignificantly higher spermatozoal concentration, and score ofspermatozoal activity (P<0.05).â‘¡ Small and large-dose groups have significantly greaterconcentration of andrusol in serum and ratio of weight between testisand body than those of model group(P<0.05).â‘¢ The above-mentioned effects were significant in small-dosegroup than those in large-dose group (P<0.05).Conclusion Chinese herb meihualubianjing capsule hasremarkable effect on oligospermia and asthenospermia with adose-effect relationship;the improvements on testicular andepididymal function underlie these effects.