| Objective:To observe the efficacy and safety of the. treatment of Zishenshengjingtang for Oligospermia and AsthenospermiaMethods:The method of this study is randomized and parallel-group. In accordance with the minimum requirements of the statistical sample, this study needs144patients.144cases met the inclusion criteria, subjects were divided into oligozoospermia group and Asthenospermia group.In each group is72cases. The two groups were divided into treatment group (Zishenshengjingtang group) and control group (Wu Zi Yan Zong oral group) and each group is36cases. Treatment group using the Zishenshengjingtang, consists of: Rehmannia, antler, yam, cornus, wolfberry fruit, dodder seed, angelica, Poria, Atractylodes, raspberry, plantain seed, Schisandra and so on. Decoction,200ml, bid. The control group Yanzong oral solution, each10ml bid. Both groups were treated for12weeks for the1course of treatment, before treatment,6weeks and12weeks to check Semen. Endpoint sperm density, sperm motility, traditional Chinese medicine syndrome:before and after treatment were observed. Security means:close observation of clinical adverse events.Results:The oligozoospermia were observed72cases. The treatment group6and12weeks before treatment, sperm density was significantly improved (P<0.05).6and12weeks in the control group before treatment, sperm density was significantly improved (P<0.05). Significant difference (P<0.05) between the two groups, experimental group was better than the control group. With the increase of treatment time,12weeks of the experimental group were significantly better than six weeks. Group were compared between the two groups improved significantly (P <0.05) in the TCM syndromes of change compared with before treatment group between the experimental group than the control group.(P<0.05).Asthenospermia patients were observed in72cases, the treatment group at6and12weeks the sperm Class A sperm before treatment, A+B class sperm showed significant improvement (P<0.05). The control group in the6and12weeks of treatment, the treatment group sperm, A+B class sperm were significantly improved (P<0.05). A level of sperm in the12weeks of treatment, A+B class sperm are better than six weeks of treatment. Significant difference (P<0.05) between the two groups, experimental group was better than the control group. Test the efficacy of12weeks than6weeks (P<0.05). Group were compared between the two groups improved significantly (P<0.05) in the TCM syndromes of change compared with before treatment group between the experimental group than the control group.(P <0.05).The Oligozoospermia merge asthenospermia compare with the asthenospermia. The two groups of sperm motility has improved significantly compared with before treatment (P<0.05). Between the two groups is relatively weak sperm group was better than the the oligozoospermia merger asthenospermia group (P<0.05).Conclusion:Treatment of Zishenshengjingtang was good for the treatment of patients with oligospermia and asthenospermia. |
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