| Objective: To observe the influence of exogenous nitric oxide on the healing stage, the growth of granulation tissue and the proliferation of epidermic cells by making the wound model on the back of rats which interfered in sodium nitroferricyanide in different concentrations. To reveal the expressive location and quantity of nitric oxide synthase during the wound healing by immunohistochemistry. To observe the quantity of fibroblasts and collagen fibers in several stages during the healing by light microscope. To detect the content of hydroxyproline in granulation tissue by histochemistry. To study the dose-effect relationship that nitric oxide has with preventing pathological scars from forming and promoting wound healing and its metabolism, through which a theoretic basis that some nitric oxide donors could be used clinically to preventing pathological scars from forming and promoting wound healing was explored.Methods: 1. laboratory animal: 60 male and healthy Wistar rats were weighed and ordered. 2. The rats were divided into 5 groups randomly. Twelve animals were used in each treatment and control group: that is the control group (5% glucose solution), the treatment group A(0.5mmol/L SNP),...
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