Expression Of Skp2, LC In The Cacinogenesis Of Cervical Squamous Cell Carcinoma And Its Relationship With HPV, EBV Infection

Objective: Cervical cancer is the second most common cause of cancer-related deaths in women. Worldwide incidence of almost half a million new cases annually, second only to breast cancer. Screening for cervical cancer widely available has reduced its incidence. Pathogenesis of cervical cancer is associated with many factors and phases. In the past decades, laboratory and clinical researches into different aspects of cervical carcinoma had been performed, but the carcinogenesis of cervical carcinoma is still not clear enough.Revelation of the connection between the human papillomavirus (HPV) and cervical neoplasia and invasive cervical cancer is the new focus on cervical carcinoma. Many researches have provided overwhelming evidence for an etiologic role for infection with certain types of HPV as the primary cause of cervical cancer. Epstein-Barr virus (EBV) has been implicated in the pathogenesis of Burkitt's lymphoma, Hodgkin's disease, non-Hodgkin's lymphoma, nasopharyngeal carcinoma, NK/T lymphoma. The presence of this virus has also been associated with epithelial malignancies arising in the gastric region, the breast, the lung and the cervix, although some...