Carnosine Eyedrops Inhibits Early Stages Of Retinal Microvascular Lesions In Diabetic Rats

Objective:To establish an animal model of diabetes with long-term, stable hyperglycemia and used to assess retinopathy. To investigate the morphologic changes of microvascular lesions, as well as the changes of the immunoreative of receptor for advanced glycation end products (RAGE) and intercellular cell adhesion molecule-1 (ICAM-1) of vascular in the early stages of diabetic rats. To explore the effect of camosine eyedrops on diabetes-induced retinal vascular lesions and the immunoreative of RAGE and ICAM-1.Methods:1. Twenty five male Sprague-Dawley rats weighing 120±20 g received a single65 mg/kg intraperitoneal injection of 10 g/L streptozotocin (STZ) dissolved in...