Apoptosis In Epileptic Foci Of Patients With Intractable Epilepsy And Its Mechanisms

Epilepsy (EP) is the most serious brain disorder in every country. In China, the prevalence is about 7 %o and the number of patients is over 8 million, with an increase of 270, 000 per year. It is a chronic neurological disease, which is caused by a sudden surge of electrical activity in the brain and characterized by recurrent and sudden disturbances of central nervous system (CNS). Suddenness and recurrence are its characteristics. So far, epileptogenesis is still unknown. Resent years apoptotic meory is getting more and more attention in this field. It is recognized that neuronal apoptosis plays an important role in the process of EP. Research on resected epileptic foci of patients with intractable epilepsy may help to explore the epileptogenesis and provide a theoretical base for clinical treatment.Objectives Apoptosis, known as a form of programmed cell death (PCD), is a physiological process for killing cells after certain stimuli and performed by a highly ordered molecular cascade that is typically energy-dependent and may involve new gene transcription. We observe apoptosis in surgically resected epileptic foci of patients with intractable epilepsy and explore its roles in epileptogenesis. Mitochondria are important and ubiquitous intracellular organelles, by which over 90% of adenosine triphosphate (ATP) is produced. In the intrinsic apoptosis pathway, mitochondria play a central role and even decide the fate of the cell. In order to provide a theory...