The Correlation Between Insulin Resistance, Hyperuricemia And Nondipper Hypertension And Its Clinical Significance

Objective: This study sought to find out the correlation between insulin resistance, hyperuricemia and nondipper hypertension, and to explore the relationship between nondipper hypertension and various of metabolic disorders, thus to provide new ways and methods for reducing the risk of cardiovarscular events and improving the prognosis of patients with nondipper hypertension.Method: 71 patients with essential hypertension were divided into non-dipper group (NDIP, n=44) and dipper group (DIP, n=27) according to 24 hour ambulatory blood pressure monitoring, and were detected fast plasma glucose, serum uric acid, plasma lipids, liver and renal function, and retained the blood sample to detect plasma immunoreactive insulin (IRI), true insulin (TI) and proinsulin (PI);in addition, 40 normal controls were chosen to detect IRI, TI and PI as well as fasting plasma glucose, serum uric acid, plasma lipids, liver and renal function. All those with diabetes, coronary heart disease and malignancy were excluded in our study. The method of traditional radioimmunoassay were used for detecting IRI, for detecting TI and PI, the method of monoclonal antibody radioimmunoassay was used. Two types of index of insulin resistance ( HOMA-IR-1, HOMA-IR-2) were calculated.Results: The mean plasma levels of IRI, TI, PI and the indexes of HOMA-IR-1, HOMA-IR-2 were all obviously higher in hypertension group than those in control group (P<0.05), the mean plasma level of uric acid was also significantly higher in hypertension group (P<0.01); the mean plasma levels of IRI and TI in NDIP group were all obviously higher than those in DIP group (P<0.05), the indexes of HOMA-IR-1, HOMA-IR-2 in NDIP group were all significantly higher than those in DIP group, the mean plasma level2...