Serum Levels Of VEGF, Adhesion Molecules In Patients With Cerebral Infarction And Immune Cells In Patients With Advanced Cancer As Well As Their Clinical Significance

Objective: The serum levels of GMP-140, sICAM-1 and VEGF levels in patients with Cerebral Infarction and circulating CD8+CD28+(CTL), CD8+CD28-(Ts) and NK in patients with advance cancer were investigated to explore the roles of these molecules and immune cells in Cerebral Infarction and advance cancer, so as to provide the clinic indications of the pathological states and the prognosis of the patients.Methods: Serum levels of GMP-140, sICAM-1 and VEGF were detected by enzyme linked immunosorbent assay (ELISA) in 80 patients with Cerebral Infarction and 30 healthy subjects. Circulating levels of CD8+CD28+(CTL), CD8+CD28-(Ts) and NK from 65 advanced cancer patients and 20 healthy controls were assayed by flow cytometry.The correlations were analyzed with regression coefficient between these variates.Results: Cerebral Infarction: (1) The serum GMP-140,sICAM-1 and VEGF levels were significantly higher in Cerebral Infarction than those in healthy subjects(p<0.05). Significant statistical correlations were observed among these three factors (p<0.05). (2)The expression of GMP-140, sICAM-1 and VEGF was closely correlated with the size of Cerebral Infarction (p<0.05). (3)The level of GMP-140, sICAM-1 and VEGF was not correlated to the location of lesion (p>0.05).The decreased percentages of CD8+CD28+(CTL) and NK cells, the elevated percentages of CD8+CD28-(Ts) cells were observed in the peripheral blood of advance cancer as compared with those of the control group (p<0.05).Conclusions: The serum levels of GMP-140,sICAM-1 and VEGF as well as...