The Changes Of Memory And Their Correlations To S-100β Protein As Well As Neuron-Spicific Enolase In Patients With Obstructive Sleep Apnea-Hypopnea Syndrome

OBJECTIVE: To explore the possible mechanism of brain damage and memory impairment in patients with obstructive sleep apnea hypopnea syndrome(OSAHS) by detecting the memory, serum S-100β protein ,neuron specific enolase (NSE) and analyzing the relationship among them.METHODS : Thirty patients with moderate or severe OSAHS(AHI>20/h) and twenty non-OSAHS controls were included in this study. All subjects were detected by polysomnography in the sleep laboratory and the memory of them were evaluated before PSG examination. Memory tests including point memory, association learning, picture free recall, meaningless picture recognition, face characters associated memory have been conducted. Venous blood samples on an empty stomach were collected in the next morning. Then the serum S100β protein was detected by ELISA and the serum NSE was detected by immunoradiometric assay. The relationship between memory and serum S100β as well as NSE were analyzed in both experiment group and control group. Data were expressed as arithmetic mean ± SD and to be treated statistically with SPSS 11.5 for windows software. The comparison between two groups was performed by t-test and the coefficient correlation of two variable was analyzed by linear correlation. P<0.05 indicate statistical difference, P<0.01 indicate statistically significant difference.RESULTS : Arithmetic mean of AHI in 30 patients with OSAHS is 51.12 ±...