Extraction And Inhibitory Activity To A-Glucosidase Of Sanguisorba Polysacharide From Radix Sanguisorba

PurposeTo find a New Natrul a-Glucosidase Inhibitor from natural herb medicine. a-Glucosidase Inhibitor Meterials and Methods1 , We therefor screening 14 Chinese tradition herbs made further investgate in Radix Sanguisorba that shows the strongest AGI of these herbs.2, Extracted Sanguisorba Polysacharide, Compired the inhibitory effect of Sanguisorba Polysacharide on α -glucosidase of yeast and SD Rats intestine with acarbose in vitro.3 ,Drew Lineweaver-Burk wave.4, Effect on the bood glucose level after a single oral administrate of SP to mice and SD Rats Inhibitory effect of Sanguisorba Polysacharide, after 9 days oral administrate. ResultsRadix Sanguisorba Polysaccharide shows the strongest inhibitory on α -glucosidase. ConclusionAs reported previously, α -glucosidase broadly consists of type I from yeast S.cerevisiae,and typeII from the mammalian source, and there are structural...