The Relationship Between Insulin Resistance And Endothelial Dysfunction And The Effects Of Rosiglitazone On Endothelial Function In Patients With Arteriosclerosis Obliterans

Objective: 1,The purpose of this study is to investigate the insulin resistance in ASO patients and to explore the internal correlation of IR and endothelial dysfunction in ASO patients. 2,To observe the effects of Rosiglitazone on endothelial function in ASO patients.Methods: 1,The fasting blood glucose (FBG), the fasting insulin (FIS) and lipid profile were measured in 86 ASO patients confirmed by peripheral arteriography and 26 healthy controls(group A). The insulin resistance index (IAI) was calculated in all subjects [ IAI = 1/ FBG*FIS ]. Detailed medical history was asked and clinic data was collected as well. 28 simple ASO patients selected from 86 ASO patients were enrolled as group B. The study compared the insulin resistance index (IAI) between group A and group B. 2,86 ASO patients confirmed by peripheral arteriography were divided into three groups(groupC1 , C2 and C3) of different severity of IR according to the insulin resistance index (IAI). Blood sample of regional diseased artery was collected through microcatheter. The serum nitric oxide (NO) and plasma endothelin-1 (ET-1) were measured by nitrate reductase and radioimmunoassay respectivly. High-resolution ultrasonography was applied to test the vasodilation in brachial artery diameter for flow-mediated dilation (FMD) . Then the research compare the FMD, blood NO level, blood ET-1 level, clinic characteristics, peripheral...