Effects Of Interleukin-1 On Brain Monoamine Neurotransmitter Level And Behavior Of The Rats

Background:Depression is one of the most common mental disorder, which pathogenesis is not clear now. It is believed that the dysfunctions of monoamine nerve in central nervous system and HPA axis are responsible for depression. Although the anti-depressant based on this theory is effective , there are still 30% patient of depression have no curative effect. Stress not only plays an important role in the development of depression, but also stimulates the production of IL-1 in the brain, which have extensive biological effects. Brain IL-1 induces a lot of changes in endocrine system, neurotransmission, cognition and affection. Thus, to investigate the action and pathogenesis of IL-1 in the development of depression not only contribute to better understanding of the mechanism of depression, but also provide the theory guidance to a new treatment. Objective:This study will investigates the influence of IL-1β in brain on the behavior of rats under acute or chronic stress, and its' biological mechanism via the relationship between IL-1β and monoaminetransmitter. Methods:This study includes three parts : (1) Investigation of the effect of brain IL-1β on depressivebehavior in rats, and the changes of concentration of monoamine and the activity of monoamine oxidase(MAO). (2) Effect of IL-1ra on depressive behavior, concentration of monoamine and the activity of MAO after acute stress. (3) Effect of IL-1ra on depressive behavior, concentration of monoamine and the activity of MAO after 12 days of chronic stress. Results:...