Study On The Therapeutic Mechanism Of Electro-scalp Acupuncture On Parkinson's Disease By Imaging Technique Of Cerebral Dopamine Transporter

Parkinson's disease (PD) is acknowledged as one of the refractory diseases, L-Dopa is the first medicine chosen to cure PD, but along with the disease progression, long time use of the medicine will result in the phenomena of "medicine-end" "on-off" and vegetative nerve functional disturbance. As for neurosurgery, its manipulation is complicated, risk and side effect is high and it is expensive, all of these is its shortcomings. Cell-transplanting and gene therapy are new therapies to cure PD and prove effective, their short-time effect is definitely but long-time effect is not significant. Acupuncture is an effective therapy and testified to relax the patients' suffering with PD and improve their living quality according to clinical practice. However, there is not a objective, reliable, well repeatedly and trustable index to assess the effect of the acupuncture therapy.The dopamine transporter (DAT), a protein in the presynaptic membrane on the terminal of dopaminergic projections, plays a critical role in the regulation of the extra-cellular dopamine concentration and has been considered a marker of dopamine terminal innervations. The imaging of cerebral DAT is valuable for the early diagnosis of PD, progression measurement and evaluation of medication effect of PD...