Experimental Study On Effects Of Electro-acupuncture On The Change Of Neural Function Of The Rat Model Under The Chronic Multiple Stress

ObjectiveChronic Fatigue Syndrome, which can be abbreviated to CFS, is a series of syndromeswith unclear reasons．It was officially named by Centers for Disease Control and Prevention(CDC) of the U.S government in 1988. The incidence of CFS rises year after year, whichcauses enormous economic losses. It has not been discovered the peculiar symptom and theabnormity of the laboratory examination. There are no effective treatment methods because ofits unclear etiology and pathogenesis. There is profound opinion in the theory of TCM, and itis seeking after the new effective treatment methods. Acupuncture and moxibustion has greatpredominance on treating CFS, but the study on mechanism of it has not been reported.As a non-pharmacologic therapy, with its good therapeutic effect and non-toxic andnon-side-effect characteristic, acupuncture and moxibustion has great predominance ontreating CFS. In recent years, many clinical reports illustrated that. Based on the clinicalefficiency of treating CFS by acupuncture and moxibustion and combined with the TCMclassical theory: the rat model was induced by complex stress factors to simulate the clinicalmanifestation of CFS, and then we choose the representative points to carry out theacupuncture experimental research. This paper explains the pathogenesis of CFS and theregulation mechanism of acupuncture.MethodsWister rats (male, weight 160~180g) were randomly distributed to control group, modelgroup and EA group．Model group and EA group include kidney deficiency syndrome．Allgroups except the control were exposed to complex stress,which include swimming in thecold water and ingjecting cortin for 21 days, and EA group accepted electro-acupuncturetreatment at the same time．The points were selected for electro-acupuncture: Baihui(GV20), Taixi(KI3)．Results1．Compared with control group, the model rats appeared not only physical strengthdeclining, but also hypo- activity of explore new environment and spontaneous activity, whichindicated that model rats were on the states of both physical and mental fatigue, same as theclinical manifestation of CFS patients．EA could improve the behavioral disorder andmarkedly reverse the fatigue states of the model rats．2．There were some metabolic disorders of central monoamine neurotransmitters inmodel rats----decrease of the content of NE, DA and 5-HT in the tissues of brain. EA couldregulate metabolic disorder of monoamine neurotransmitters in central nervous system.3．The level of NPY in the thalamencephalon and pituitary is higher than the control...